Impact of thyroid transcription factor-1 on clinicopathological parameters and outcome of patients with pulmonary adenocarcinoma

Background: Lung cancer is the most lethal cancer worldwide. Search for prognostic markers that allow identification of patient’s risk and selection of new therapy with better response, low recurrence, and improved survival is highly recommended. Aim: The aim of this study was to evaluate the relationship between thyroid transcription factor-1 (TTF-1) immunohistochemical expression and clinicopathological parameters and patients’ survival. Materials and methods: We analyzed a total of 97 patients with primary pulmonary adenocarcinoma diagnosed between January 2005 and December 2011. Patients’ clinicopathological characteristics were included into the analyses. After the end of therapy, all patients were followed up clinically and radiologically every 3 months during the first year and 6 monthly thereafter. TTF-1 immunostaining was performed for all cases using a streptavidin–biotin peroxidase according to the manufacturer’s protocol. Results: The immunoreactivity of TTF-1 was 83.5%. Compared with TTF-1-negative tumors, TTF-1-positive tumors were significantly associated with earlier stage, stages IA and IB (P
Source: Egyptian Journal of Pathology - Category: Pathology Tags: Original Articles Source Type: research