A genome ‐wide linkage and association analysis of imputed insertions and deletions with cardiometabolic phenotypes in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study

In conclusion, these results confirm the feasibility of imputing INDELs from array‐based single nucleotide polymorphism (SNP) genotypes. Analysis of these variants using association and linkage replicated previously identified SNP signals and identified multiple novel INDEL signals. These results support the inclusion of INDELs into genetic studies to more fully interrogate the spectrum of genetic variation.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fgepi.22042

Source: Genetic Epidemiology - April 1, 2017 Category: Epidemiology Authors: Chuan Gao, Fang ‐Chi Hsu, Latchezar M. Dimitrov, Hayrettin Okut, Yii‐Der I. Chen, Kent D. Taylor, Jerome I. Rotter, Carl D. Langefeld, Donald W. Bowden, Nicholette D. Palmer Tags: RESEARCH ARTICLE Source Type: research