Association of the type 2 diabetes mellitus susceptibility gene (IGF2BP2) with schizophrenia in an Egyptian sample

Introduction: A link between schizophrenia and diabetes has been known for over a century, long before the use of antipsychotic medications. Type 2 diabetes mellitus is an important contributor to mortality and morbidity in this condition. Insulin growth factor 2 mRNA binding protein 2 (IGF2BP2) genetic variants rs4402960 and rs1470579 have been implicated in the etiology of type 2 diabetes mellitus in Egyptians. It is possible that both disorders share a common genetic susceptibility. Aim: The current study aimed to explore single-nucleotide polymorphism 2 (IGF2BP2) polymorphisms in a sample of Egyptian first-episode schizophrenic patients and healthy controls and to study its potential correlation with severity of psychopathology. Patients and methods: Thirty male patients with first-episode schizophrenia according to International Classification of Diseases-10 criteria and 30 healthy individuals were genotyped for IGF2BP2 rs4402960 and rs1470579 variant polymorphisms. Laboratory assessment included plasma glucose, glycated hemoglobin (HbA1c), triglycerides, total cholesterol, and high-density lipoprotein cholesterol (HDL-c). Psychological measures included Mini-International Neuropsychiatric Interview, Positive and Negative Syndrome Scale, and an Interview for the Retrospective Assessment of the Onset of Schizophrenia instrument. General Health Questionnaire was applied in healthy individuals. Results: There was a statistically significant difference between the two gro...
Source: Middle East Current Psychiatry - Category: Psychiatry Tags: Original articles Source Type: research