Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study – A Randomized Clinical Trial

Over the last 20 years, studies have demonstrated that certain drugs can prolong lifespan of dogs with myxomatous mitral valve disease (MMVD) once they develop congestive heart failure (CHF). Studies first suggested that angiotensin-converting-enzyme (ACE) inhibitors could improve survival (although these have been subsequently challenged 1 –2) and almost a decade ago, a large randomized controlled trial (RCT) showed that dogs receiving pimobendan with furosemide lived longer than those receiving an ACE inhibitor with furosemide.
Source: Advances in Small Animal Medicine and Surgery - Category: Veterinary Research Authors: Tags: Guest Editorial Source Type: research