Serum uric acid level is linked to the disease progression rate in male patients with multiple system atrophy

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder that encompasses three syndromes previously considered to be separate disorders: striatonigral degeneration, olivopontocerebellar atrophy, and Shy-Drager syndrome. According to a consensus statement on MSA diagnosis, predominately parkinsonian features are associated with the MSA-P subtype, whereas predominately cerebellar features are associated with the MSA-C subtype [1]. Although the cause of MSA is still unknown, genetic and immunohistological evidence suggests that oxidative stress contributes to MSA pathogenesis [2 –4].

Source: Clinical Neurology and Neurosurgery - April 3, 2017 Category: Neurosurgery Authors: Jiro Fukae, Shinsuke Fujioka, Shosaburo Yanamoto, Akio Mori, Takahiro Nomi, Taku Hatano, Kousuke Fukuhara, Shinji Ouma, Nobutaka Hattori, Yoshio Tsuboi Tags: Original Articles Source Type: research