Alternative lengthening of telomeres and ATRX/DAXX loss can be reliably detected in FNAs of pancreatic neuroendocrine tumors

CONCLUSIONSBoth ALT and loss of ATRX/DAXX can be accurately performed on FNA specimens with adequate material. Because ALT is a fundamental mechanism of pathogenesis, the ability to determine ALT in small biospecimens has implications for the design of clinical trials. Cancer Cytopathol 2017. © 2017 American Cancer Society.

Source: Cancer Cytopathology - March 1, 2017 Category: Pathology Authors: Christopher J. VandenBussche, Derek B. Allison, Mindy K. Graham, Vivek Charu, Anne Marie Lennon, Christopher L. Wolfgang, Ralph H. Hruban, Christopher M. Heaphy Tags: Original Article Source Type: research