NFAT regulation of cystathionine {gamma}-lyase expression in endothelial cells is impaired in rats exposed to intermittent hypoxia

This study identifies the calcium-regulated transcription factor nuclear factor of activated T cells as a novel regulator of cystathionine -lyase (CSE). This pathway is basally active in mesenteric artery endothelial cells, but, after exposure to intermittent hypoxia to mimic sleep apnea, nuclear factor of activated T cells c3 nuclear translocation and CSE expression are decreased, concomitant with decreased CSE-dependent vasodilation.

Source: AJP: Heart and Circulatory Physiology - April 1, 2017 Category: Cardiology Authors: Gonzalez Bosc, L. V., Osmond, J. M., Giermakowska, W. K., Pace, C. E., Riggs, J. L., Jackson-Weaver, O., Kanagy, N. L. Tags: RESEARCH ARTICLE Source Type: research