Exercise training decreases NADPH oxidase activity and restores skeletal muscle mass in heart failure rats

This study demonstrates, for the first time, the contribution of aerobic exercise training (AET) in decreasing muscle NADPH oxidase activity associated with reduced reactive oxygen species production and systemic inflammation, which diminish NF-B overactivation, p38 phosphorylation, and ubiquitin proteasome system hyperactivity. These molecular changes counteract plantaris atrophy in trained myocardial infarction-induced heart failure rats. Our data provide new evidence into how AET may regulate protein degradation and thus prevent skeletal muscle atrophy.

Source: Journal of Applied Physiology - April 1, 2017 Category: Physiology Authors: Cunha, T. F., Bechara, L. R. G., Bacurau, A. V. N., Jannig, P. R., Voltarelli, V. A., Dourado, P. M., Vasconcelos, A. R., Scavone, C., Ferreira, J. C. B., Brum, P. C. Tags: RESEARCH ARTICLE Source Type: research