A neurobiologist's attempt to understand persistent pain

Publication date: Available online 30 March 2017 Source:Scandinavian Journal of Pain Author(s): Per Brodal This topical review starts with a warning that despite an impressive wealth of neuroscientific data, a reductionist approach can never fully explain persistent pain. One reason is the complexity of clinical pain (in contrast to experimentally induced pain). Another reason is that the “pain system” shows degeneracy, which means that an outcome can have several causes. Problems also arise from lack of conceptual clarity regarding words like nociceptors, pain, and perception. It is, for example, argued that “homeoceptor” would be a more meaningful term than nociceptor. Pain experience most likely depends on synchronized, oscillatory activity in a distributed neural network regardless of whether the pain is caused by tissue injury, deafferentation, or hypnosis. In experimental pain, the insula, the second somatosensory area, and the anterior cingulate gyrus are consistently activated. These regions are not pain-specific, however, and are now regarded by most authors as parts of the so-called salience network, which detects all kinds of salient events (pain being highly salient). The networks related to persistent pain seem to differ from the those identified experimentally, and show a more individually varied pattern of activations. One crucial difference seems to be activation of regions implicated in emotional and body-information processing in persistent pain. ...
Source: Scandinavian Journal of Pain - Category: Anesthesiology Source Type: research