Talin gets SHANKed in the fight for integrin activation
Nature Cell Biology 19, 265 (2017).
doi:10.1038/ncb3501
Authors: Paul Atherton & Christoph Ballestrem
Genetic mutations in the SHANK family of proteins are linked to multiple neuropsychiatric disorders including autism spectrum disorders. A study now elucidates critical roles for SHANK in regulating integrin-mediated cell–extracellular matrix adhesion, by sequestering integrin activators.
Source: Nature Cell Biology - Category: Cytology Authors: Paul Atherton Christoph Ballestrem Tags: News and Views Source Type: research