Talin gets SHANKed in the fight for integrin activation

Nature Cell Biology 19, 265 (2017). doi:10.1038/ncb3501 Authors: Paul Atherton & Christoph Ballestrem Genetic mutations in the SHANK family of proteins are linked to multiple neuropsychiatric disorders including autism spectrum disorders. A study now elucidates critical roles for SHANK in regulating integrin-mediated cell–extracellular matrix adhesion, by sequestering integrin activators.

http://feeds.nature.com/~r/ncb/rss/current/~3/-QZAjwh7iCE/ncb3501

Source: Nature Cell Biology - March 31, 2017 Category: Cytology Authors: Paul Atherton Christoph Ballestrem Tags: News and Views Source Type: research