To cleave or not to cleave: therapeutic gene editing with and without programmable nucleases

Nature Reviews Drug Discovery 16, 296 (2017). doi:10.1038/nrd.2017.42 Authors: Tod M. Woolf, Channabasavaiah B. Gurumurthy, Frederick Boyce & Eric B. Kmiec In recent years, pioneering clinical studies involving the use of programmable nucleases to achieve gene editing have begun to evaluate the therapeutic potential of such approaches. For example, Sangamo BioSciences has reported successful proof-of-concept clinical studies to treat HIV infection using an engineered zinc-finger nuclease
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Correspondence Source Type: research