Drug toxicity: Cardiac safety index for TKIs

Nature Reviews Drug Discovery 16, 240 (2017). doi:10.1038/nrd.2017.52 Author: Sarah Crunkhorn Tyrosine kinase inhibitors (TKIs) represent efficacious anticancer agents, but their use has been linked with severe cardiotoxicity. Here, Sharma et al. generated human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes, hiPSC-derived endothelial cells and hiPSC-derived cardiac fibroblasts to evaluate the cardiotoxicities of 21 US FDA-approved

http://feeds.nature.com/~r/nrd/rss/current/~3/_Hzc8NWD6sk/nrd.2017.52

Source: Nature Reviews Drug Discovery - March 30, 2017 Category: Drugs & Pharmacology Authors: Sarah Crunkhorn Tags: Research Highlight Source Type: research