Higher prevalence of colonization with Gardnerella vaginalis and gram-negative anaerobes in patients with recurrent miscarriage and elevated peripheral natural killer cells

Recurrent miscarriage (RM) is defined by the WHO as three or more successive spontaneous miscarriages before gestational week 22 and affects about 1-3% of couples during their reproductive years (Carrington et al., 2005). Risk factors for RM include parental genetic disorders, uterine anatomic malformations, endocrine dysfunctions and haemostatic disorders (Carrington et al., 2005; Franssen, 2005; Porcu et al., 2000; Rodger et al., 2008; Toth et al., 2010). Whether vaginal infections are additional risk factors is part of an ongoing debate and international guidelines do not recommend routine screening for vaginal infections (Toth et al., 2015).
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research