Selection and identification of specific glycoproteins and glycan biomarkers of macrophages involved in Mycobacterium tuberculosis infection
Macrophages are the primary host target cells of Mycobacterium tuberculosis (M.tb). However, little is known about the changes of membrane glycopatterns of macrophages in response to M. tb infection. Using lectin microarrays we compared the differential expression of glycopatterns of macrophages upon stimulation with the heat-inactivated virulent M.tb H37Rv or attenuate M.tb H37Ra. We found that widespread alteration of macrophage membrane glycopatterns were induced by the heat-inactivated virulent M.
Source: Tuberculosis - Category: Respiratory Medicine Authors: Xiao-Lei Tang, Chun-Hui Yuan, Quanquan Ding, Yidan Zhou, Qin Pan, Xiao-Lian Zhang Source Type: research
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