Impact of the amino acid sequence on the conformation of side chain lactam ‐bridged octapeptides

In conclusion, the Lys‐Asp‐(i,i + 4)‐lactam bridge may succeed or fail in the stabilization of short helices, depending on the primary structure. Moreover, computational methods may be valuable tools to discriminate helix‐prone from non‐helix‐prone peptide‐based macrolactams. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd. A series of peptide‐based macrolactams has been synthesized, and their helix propensity has been assessed by CD spectroscopy and computational methods. The results indicate that the conformational features of the macrolactams are significantly affected by both the inner and outer residues.
Source: Journal of Peptide Science - Category: Biochemistry Authors: Tags: Special Issue Article Source Type: research