Behavioral and neuroanatomical analyses in a genetic mouse model of 2q13 duplication

In this study, we generated bacterial artificial chromosome‐based transgenic mice, called 2q13 dup, that recapitulate human chromosome 2q13 duplication and contain one extra copy of the Nphp1 transgene. To analyze any behavioral alterations in 2q13 dup mice, we conducted a battery of behavioral tests. Although 2q13 dup mice show no significant differences in social behavior, they show deficits in spontaneous alternation behavior and fear memory. We also carried out magnetic resonance imaging to confirm whether copy number gain in this locus affects the neuroanatomy. There was a trend toward a decrease in the cerebellar paraflocculus of 2q13 dup mice. This is the first report of a genetic mouse model for human 2q13 duplication. We generated bacterial artificial chromosome‐based transgenic mice, called 2q13 dup, that recapitulate human chromosome 2q13 duplication and contain one extra copy of the Nphp1 transgene. Although 2q13 dup mice show no significant differences in social behavior, they display deficits in spontaneous alternation behavior and fear memory. MRI shows a trend towards a decrease in the cerebellar paraflocculus of 2q13 dup mice.
Source: Genes to Cells - Category: Genetics & Stem Cells Authors: Tags: Original Article Source Type: research