Is bad luck the leading cause of cancer?

Conclusion This analysis of global cancer registry data proposes simple chance as the third possible factor behind cancer-causing gene mutations, alongside well-established genetic and environmental factors. The possibility that random gene mutations can occur when the body's cells repeatedly divide is obviously highly plausible and not really that revolutionary a theory. However, these researchers have tried to quantify exactly what proportion of cancers could be down to chance. This brings us to the greatest limitation of this research: these are only estimates. As the researchers themselves point out: "The actual contribution of [chance] mutations to any particular cancer type cannot be reliably estimated from such correlations." The researchers estimated random chance could be behind just over a third of cancers worldwide. It's not immediately apparent why on the CRUK database this proportion suddenly leaps to two-thirds. But we don't know that these figures are accurate, and they won't necessarily apply to any individual cancers. The fact chance may be involved also doesn't take away the importance of modifiable risk factors in cancer development. Though the CRUK database indicated two-thirds of 32 cancers could be down to chance, CRUK still estimate 42% of these cases could be prevented. As the study's authors pointed out: "Primary prevention is the best way to reduce cancer deaths. Recognition of a third contributor to cancer – chance mutations ...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Genetics/stem cells Source Type: news