Dying cells actively regulate adaptive immune responses

Nature Reviews Immunology 17, 262 (2017). doi:10.1038/nri.2017.9 Authors: Nader Yatim, Sean Cullen & Matthew L. Albert Dying cells have an important role in the initiation of CD8+ T cell-mediated immunity. The cross-presentation of antigens derived from dying cells enables dendritic cells to present exogenous tissue-restricted or tumour-restricted proteins on MHC class I molecules. Importantly, this pathway has been implicated
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research