T cells: Successful checkpoint blockade requires positive co-stimulation

Nature Reviews Immunology 17, 215 (2017). doi:10.1038/nri.2017.32 Author: Alexandra Flemming PD1 inhibits T cell activation by suppressing co-stimulation through CD28, and anti-PD1 therapy requires CD28 stimulation for therapeutic efficacy.

http://feeds.nature.com/~r/nri/rss/current/~3/DzBF211aoyg/nri.2017.32

Source: Nature Reviews Immunology - March 27, 2017 Category: Allergy & Immunology Authors: Alexandra Flemming Tags: Research Highlight Source Type: research

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