Elucidating the aberrant brain regions in bipolar disorder using T1-weighted/T2-weighted magnetic resonance ratio images

Although diffusion tensor imaging (DTI) have revealed brain abnormalities in bipolar disorder (BD) subjects, DTI methods might not detect disease-related abnormalities in the white matter (WM) where nerve fibers are crossing. We investigated BD myelin-related abnormal brain regions in both gray matter and WM for 29 BD and 33 healthy control (HC) participants using T1-weighted (T1w)/T2-weighted (T2w) ratio images that increase myelin-related contrast irrespective of nerve fiber orientation. To check effect of the brain volume, the results were compared with those of voxel-based morphometry (VBM).

Source: Psychiatry Research: Neuroimaging - March 25, 2017 Category: Psychiatry Authors: Takuya Ishida, Tomohiro Donishi, Jun Iwatani, Shinichi Yamada, Shun Takahashi, Satoshi Ukai, Kazuhiro Shinosaki, Masaki Terada, Yoshiki Kaneoke Source Type: research