The use of kinase inhibitors in solid organ transplantation

Despite the efficacy of current immunosuppression regimes used in solid organ transplantation, graft dysfunction, graft lost and antibody-mediated rejection, continue to be problematic. As a result; clear attraction in exploiting key potential targets controlled by kinase phosphorylation have led to a number of studies exploring the use of these drugs in transplantation.AimIn this review, we consider the role of tyrosine kinase as a target in transplantation and summarise the relevant studies on kinase inhibitors that have been reported to date.
Source: Transplantation Reviews - Category: Transplant Surgery Authors: Source Type: research