A novel network analysis tool to identify relationships between disease states and risks for red blood cell alloimmunization

We hypothesized that diagnoses may be associated with alloantibody ‘responder’ status and examined associations between disease states and alloimmunization. Patients with ≥1 alloantibody and non‐alloimmunized controls were analysed. Pearson's coefficients were calculated to determine associations between alloimmunization and diseases; significant correlations were selected to construct a network. Inflammatory disorders and diseases requiring chronic transfusion support were associated with responder status. Mitigation steps may be considered in patients with these disorders.

Source: Vox Sanguinis - March 23, 2017 Category: Hematology Authors: R. Celli, W. Schulz, J. E. Hendrickson, C. A. Tormey Tags: Short Report Source Type: research