Transformation Diffusion Reconstruction of Three-Dimensional Histology Volumes from Two-Dimensional Image Stacks

Traditional histology, the study of tissue microarchitecture, originated in the 17th c. with first applications of microscopy to animal-derived samples by Marcello Malpighi. It has become the gold standard for structural description of cells and tissue, serving important functions in clinical diagnosis of pathologies. Traditional histology produces two-dimensional (2D) images, resolving cellular and sub-cellular detail in slices that typically are several micrometers thick. A wide variety of chromatic stains, developed since the 18th c., enable cell labelling (e.g.

Source: Medical Image Analysis - March 22, 2017 Category: Radiology Authors: Ram ón Casero, Urszula Siedlecka, Matthew Gibb, Jürgen E. Schneider, Peter Kohl, Vicente Grau Source Type: research