Brain-Derived Neurotrophic Factor Val66Met Genotype Modulates Amygdala Habituation

A deficit in amygdala habituation to repeated emotional stimuli may be an endophenotype of disorders characterized by emotion dysregulation, such as borderline personality disorder (BPD). Amygdala reactivity to emotional stimuli is genetically modulated by brain-derived neurotrophic factor (BDNF) variants. Whether amygdala habituation itself is also modulated by BDNF genotypes remains unknown. We used imaging-genetics to examine the effect of BDNF Val66Met genotypes on amygdala habituation to repeated emotional stimuli.

Source: Psychiatry Research: Neuroimaging - March 21, 2017 Category: Psychiatry Authors: M. Mercedes Perez-Rodriguez, Antonia S. New, Kim E. Goldstein, Daniel Rosell, Qiaoping Yuan, Zhifeng Zhou, Colin Hodgkinson, David Goldman, Larry J. Siever, Erin A. Hazlett Source Type: research