{alpha}-B Crystallin Reverses High Diastolic Stiffness of Failing Human Cardiomyocytes [Original Articles]

Conclusions— High cardiomyocyte stiffness contributed to stiffness of failing human myocardium because of reduced titin distensibility. The latter resulted from an absent stiffness-lowering effect of baseline phosphorylation and from titin aggregation. High cardiomyocyte stiffness was corrected by α-B crystallin probably through relief of titin aggregation.
Source: Circulation: Heart Failure - Category: Cardiology Authors: Tags: Pathophysiology, Translational Studies, Heart Failure Original Articles Source Type: research