Quantifying the shifting landscape of B cell immunodominance

Nature Immunology 18, 367 (2017). doi:10.1038/ni.3695 Authors: Gordon A Dale, Jessica R Shartouny & Joshy Jacob Antibodies to neutralizing epitopes on hemagglutinin exhibit reproducible dynamic immunodominance patterns over time. Early responses target largely the Cb site, followed by Sb dominance and a concomitant rise in the diversity of neutralizing-antibody specificities.
Source: Nature Immunology - Category: Allergy & Immunology Authors: Tags: News and Views Source Type: research