The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain

Nature Reviews Molecular Cell Biology 18, 263 (2017). doi:10.1038/nrm.2017.10 Authors: Kevin M. Harlen & L. Stirling Churchman The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II (Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the transcription process, the CTD is dynamically modified by post-translational modifications, many of which facilitate or hinder the recruitment of
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Review Source Type: research