Chromosome biology: Trimethylation of CENP-A supports mitotic fidelity

Nature Reviews Molecular Cell Biology 18, 213 (2017). doi:10.1038/nrm.2017.30 Author: Paulina Strzyz Centromeres are chromosomal sites for kinetochore assembly, which supports the attachment of spindle microtubules and chromosome segregation. The centromere is specified by the incorporation of the histone H3 variant CENP-A into nucleosomes. CENP-A interacts with components of the constitutive centromere-associated network (CCAN), which forms the
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Research Highlight Source Type: research