Expression of miRNA-21, miRNA-107, miRNA-137 and miRNA-29b in meningioma

Meningiomas are common central nervous system (CNS) tumors, accounting for approximately 30% of all intracranial tumors [1]. Specific gene dysfunctions have been implicated in the pathogenesis of these tumors, including the inactivation of tumor suppressor genes, or excessive expression of oncogenes [2]. In addition to deletions in chromosome 22, which are the most common abnormality detected in meningiomas, loss of chromosome 1p, 3p, 6q, 10q, and 14q were also observed, particularly in atypical or malignant meningiomas.

Source: Clinical Neurology and Neurosurgery - March 20, 2017 Category: Neurosurgery Authors: Salim Katar, Oguz Baran, Sevket Evran, Serdar Cevik, Enes Akkaya, Gozde Baran, Veysel Antar, Hakan Hanimoglu, Mehmet Yasar Kaynar Source Type: research