Heat shock protein expression in cerebral X ‐linked adrenoleukodystrophy reveals astrocyte stress prior to myelin loss

ConclusionsThe finding that astrocytes show signs of cellular stress before demyelination suggests that they play a major role early in the pathogenesis of cerebral X‐ALD, and may therefore be involved in the initiation of inflammation and demyelination.This article is protected by copyright. All rights reserved.

Source: Neuropathology and Applied Neurobiology - January 31, 2017 Category: Neurology Authors: Anna Lena G örtz, Laura A.N. Peferoen, Wouter H. Gerritsen, Johannes M. van Noort, Marianna Bugiani, Sandra Amor Tags: Original Article Source Type: research