Rotigotine may control drooling in patients with Parkinson ’s Disease: preliminary findings

Parkinson ’s Disease (PD) is a progressive neurodegenerative disorder whose pathological hallmark is the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Associated with the “cardinal signs” (tremor, bradykinesia, rigidity and postural instability), patients with PD also develo p a number of disabling non-motor features, including cognitive impairment and psychiatric symptoms, sleep disorders, pain and autonomic dysfunctions, gastrointestinal disturbances [1]. Gastrointestinal (GI) disturbances include severe manifestations (dysphagia, reduced motility, constipation, infec tions, intestinal occlusion, abnormal absorption of drugs), but also disabling and neglected symptoms such as drooling that may significantly affect patients’s quality of life [2].

Source: Clinical Neurology and Neurosurgery - March 17, 2017 Category: Neurosurgery Authors: Tommaso Schirinzi, Paola Imbriani, Alessio D ’Elia, Giulia Di Lazzaro, Nicola Biagio Mercuri, Antonio Pisani Source Type: research