Effects of Late Sodium Current Blockade on Ventricular Refibrillation in a Rabbit Model [Original Article]

Conclusions— Late Na+ current inhibition during long-duration VF reduces the susceptibility to subsequent refibrillation, partially by mitigating dysregulation of intracellular Ca2+. These results suggest the potential therapeutic use of ranolazine and GS-967 and call for further testing in cardiac arrest models.
Source: Circulation: Arrhythmia and Electrophysiology - Category: Cardiology Authors: Tags: Basic Science Research Original Article Source Type: research