Inhibitors of soluble epoxide hydrolase minimize ischemia ‐reperfusion induced cardiac damage in normal, hypertensive and diabetic rats

ConclusionsProphylactic treatment with sEH inhibitors decreased myocardial damage due to IR, hypertension and diabetes, and decreased endothelial dysfunction created by diabetes and hypertension. Therefore, inhibitors of sEH are useful probes to study cardiovascular pathology and inhibition of the sEH is a potential approach in the management of IR‐induced cardiac damage and endothelial dysfunction related cardiovascular disorders.This article is protected by copyright. All rights reserved.

Source: Cardiovascular Therapeutics - March 15, 2017 Category: Cardiology Authors: Oliul Islam, Prashanth Patil, Sumanta K. Goswami, Rema Razdan, Mohammed N. Inamdar, Mohammed Rizwan, Jubin Mathew, Bora Inceoglu, Kin S. Stephen Lee, Sung H. Hwang, Bruce D. Hammock Tags: Original Research Article Source Type: research