TLR4 Promotes Breast Cancer Metastasis via Akt/GSK3 β/β‐catenin Pathway upon LPS Stimulation

This study substantiates and further extends the relationship between TLR4 activation by LPS and breast cancer using both in vitro and in vivo models. The results suggest that the Akt/GSK3β/β‐catenin signal transduction pathway may serve as a viable clinical treatment target in breast cancer. This article is protected by copyright. All rights reserved.

Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology - March 13, 2017 Category: Molecular Biology Authors: Jun Li, Jing Yin, Wenzhi Shen, Ruifang Gao, Yanhua Liu, Yanan Chen, Xiru Li, Chenghu Liu, Rong Xiang, Na Luo Tags: Full Length Article Source Type: research