Asymmetric reductive resolution of racemic sulfoxides by recombinant methionine sulfoxide reductase from a pseudomonas monteilii strain

In this study, the methionine sulfoxide reductase A from a pseudomonas monteilii strain (pmMsrA) was reported to synthesize optically active sulfoxides (R)-1a-4a, through asymmetric biocatalytic reductive resolution. Several biotransformation parameters including the reaction time, cell density, and substrate concentration were optimized. Moreover, Substrate scope of pmMsrA catalyzed asymmetric reductive resolution was investigated, which gave chiral (R)-1a-4a with 61%-97% ee.

Source: Journal of Molecular Catalysis B: Enzymatic - March 11, 2017 Category: Biochemistry Source Type: research