The bone marrow microenvironment – Home of the leukemic blasts
Acute Myeloid Leukaemia (AML) is a genetically, biologically and clinically heterogeneous set of diseases, which are characterised by an increased growth of abnormal myeloid progenitor cells within the bone marrow (BM). Ex-vivo AML exhibits a high level of spontaneous apoptosis. Furthermore, relapse for patients achieving remission occurs from minimal residual disease harboured within the BM microenvironment. Taken together, these observations illustrate the importance of the BM microenvironment in sustaining AML.
Source: Blood Reviews - Category: Hematology Authors: Manar S Shafat, Bruno Gnaneswaran, Kristian M Bowles, Stuart A Rushworth Tags: Review Source Type: research