Extended Low Dose Dexamethasone Suppression Test for Diagnosis of Atypical Cushing's Syndrome in Dogs

The purpose of this study was to evaluate extension of the low dose dexamethasone suppression test from 8 h to 12 h to detect possible hypercortisolemia associated with atypical hyperadrenocorticism (AHAC). Twelve client-owned dogs were enrolled in the study: 6 healthy dogs (group 1) and 6 dogs with suspected AHAC (group 2). Baseline EDTA plasma samples were collected for endogenous ACTH determination using an immunoradiometric assay. Serum samples were collected prior to and at 4, 8, 10, and 12 h post-administration of 0.01 mg/kg dexamethasone IV for cortisol concentration determination via chemiluminescent assay.

Source: Domestic Animal Endocrinology - March 11, 2017 Category: Endocrinology Authors: K.M. Fowler, L.A. Frank, F. Morandi, J.C. Whittemore Source Type: research