Inhibition of sphingosine 1-phosphate signaling ameliorates murine nonalcoholic steatohepatitis

This study describes the use of FTY720, a novel small molecule, for the amelioration of NASH in a mouse model. We demonstrate that 2-wk administration of FTY720 to mice with NASH led to a reduction in liver injury, inflammation, and fibrosis. These data provide a preclinical rationale for studying this drug in human NASH.

Source: AJP: Gastrointestinal and Liver Physiology - March 9, 2017 Category: Gastroenterology Authors: Mauer, A. S., Hirsova, P., Maiers, J. L., Shah, V. H., Malhi, H. Tags: RESEARCH ARTICLE Source Type: research