SGM-101: An innovative near-infrared dye-antibody conjugate that targets CEA for fluorescence-guided surgery

Fluorescence-guided surgery (FGS) provides surgeons with new opportunities to improve real-time cancer nodule detection and tumor margin visualization. Currently, the most important challenge in this field is the development of fluorescent dyes that specifically target tumors. We developed, characterized and evaluated SGM-101, an innovative antibody-dye conjugate in which the fluorochrome BM104, which has an absorbance band centered at 700  nm, is coupled to a chimeric monoclonal antibody (mAb) against carcinoembryonic antigen (CEA).

Source: Surgical Oncology - March 8, 2017 Category: Surgery Authors: Marian Gutowski, B érénice Framery, Martin C. Boonstra, Véronique Garambois, François Quenet, Karen Dumas, François Scherninski, Françoise Cailler, Alexander L. Vahrmeijer, André Pèlegrin Source Type: research