Intracranial Myxoid Mesenchymal Tumors with EWSR1 ‐ CREB Family Gene Fusions: Myxoid Variant of Angiomatoid Fibrous Histiocytoma or Novel Entity?

Conclusion: CNS myxoid mesenchymal neoplasms with histological and immunophenotypic similarities to myxoid variant of AFH are rare, diagnostically challenging, and harbor EWSR1‐CREB1 and also a novel EWSR1‐ CREM fusion not yet described in AFH. Therefore, it is uncertain if these tumors represent variants of AFH or a new entity. The copy number and mutational changes presented here, provide support for future studies to further clarify this issue. This article is protected by copyright. All rights reserved.

Source: Brain Pathology - March 8, 2017 Category: Neurology Authors: Tejus A. Bale, Angelica Oviedo, Harry Kozakewich, Caterina Giannini, Phani K. Davineni, Keith Ligon, Sanda Alexandrescu Tags: Research Article Source Type: research