Does percutaneous coronary stent implantation increase platelet reactivity?

High platelet reactivity (PR) values on treatment with clopidogrel are associated with an increased rate of thrombotic events after a percutaneous coronary intervention (PCI). However, we do not know the optimal timing of the performance of the PR measurements. Platelets might be activated during a PCI, which means that the timing of PR measurements, before or after PCI, could influence the outcome. In turn, this could lead to misinterpretation of the patient's response to antiplatelet therapy and a less accurate prediction of the patient's risk of thrombotic events during follow-up.

Source: Blood Reviews - March 7, 2017 Category: Hematology Authors: P.W.A. Janssen, E.A. Mol, S.M.C. Geene, E. Barbato, J.M. ten Berg Tags: Review Source Type: research