Increased cytokine production by monocytes from human subjects who consumed grape powder was not mediated by differences in dietary intake patterns

Recently, in a randomized, double-blind cross-over study, we reported that consumption of grape powder by obese human subjects increased the production of the pro-inflammatory cytokines interleukin (IL)-1 β and interleukin-6 by peripheral blood monocytes after ex vivo-stimulation with bacterial lipopolysaccharide (LPS) compared to the placebo treatment. We hypothesized that dietary grape powder increased the production of these cytokines by stimulated monocytes. To test this hypothesis, we used 24h dietary recall data to determine if differences in dietary patterns played a role in increased cytokine production.

Source: Nutrition Research - March 6, 2017 Category: Nutrition Authors: Susan J. Zunino, Nancy L. Keim, Darshan S. Kelley, Ellen L. Bonnel, Elaine C. Souza, Janet M. Peerson Source Type: research