A local adjustment strategy for the initialization of dynamic causal modelling to infer effective connectivity in brain epileptic structures

This paper addresses the question of effective connectivity in the human cerebral cortex in the context of epilepsy. Among model based approaches to infer brain connectivity, spectral Dynamic Causal Modelling is a conventional technique for which we propose an alternative to estimate cross spectral density. The proposed strategy we investigated tackles the sub-estimation of the free energy using the well-known variational Expectation-Maximization algorithm highly sensitive to the initialization of the parameters vector by a permanent local adjustment of the initialization process.
Source: Computers in Biology and Medicine - Category: Bioinformatics Authors: Source Type: research