Efficient Estimation of Realized Kinship from Single Nucleotide Polymorphism Genotypes [Statistical Genetics and Genomics]

Realized kinship is a key statistic in analyses of genetic data involving relatedness of individuals or structure of populations. There are several estimators of kinship that make use of dense SNP genotypes. We introduce a class of estimators, of which some existing estimators are special cases. Within this class, we derive properties of the estimators and determine an optimal estimator. Additionally, we introduce an alternative marker weighting that takes allelic associations [linkage disequilibrium (LD)] into account, and apply this weighting to several estimators. In a simulation study, we show that improved estimators are obtained (1) by optimal weighting of markers, (2) by taking physical contiguity of genome into account, and (3) by weighting on the basis of LD.

Source: Genetics - March 6, 2017 Category: Genetics & Stem Cells Authors: Wang, B., Sverdlov, S., Thompson, E. Tags: Statistical Genetics and Genomics Source Type: research