Proteomics analysis of bronchoalveolar lavage fluid (BALF) from lung cancer patients using label-free mass spectrometry

Conclusion The results presented in this study indicate that BALF is an important proximal biofluid for the discovery and identification of candidate lung cancer biomarkers. General Significance There is good correlation between the trend of protein abundance levels in BALF and that of plasma which validates this approach to develop a blood biomarker to aid lung cancer diagnosis, particularly in the era of lung cancer screening. The protein signatures identified also provides insight into the molecular mechanisms associated with lung malignancy.
Source: BBA Clinical - Category: Biochemistry Source Type: research