Maternal high salt diet altered Adenosine ‐mediated vasodilatation via PKA/BK channel pathway in offspring rats

ConclusionsPrenatal HS diets altered Adenosine‐mediated coronary artery vasodilatation in the offspring, which was linked to downregulation of cAMP/PKA/BK channel pathway. Adenosine mediates vasodilatation mostly via A2A adenosine receptor, A2A receptors are coupled to GS proteins and activate adenylate cyclase, leading to cyclic Adenosine 5′‐monophosphate (cAMP) accumulation and subsequent activation of protein kinase A (PKA). The activation of K+ channels by PKA leads to the dilatation of vessels. The present study demonstrates that prenatal high‐salt diet changes adenosine‐induced vascular dilation in offspring coronary arteries, which is probably associated with the change of cAMP/PKA/K+ channel signaling pathway.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fmnfr.201600963

Source: Nahrung / Food - March 2, 2017 Category: Nutrition Authors: Jue Wu, Na Li, Yanping Liu, Weisheng Li, Axin He, Di Zhu, Xueqin Feng, Bailin Liu, Ruixiu Shi, Yujuan Zhang, Juanxiu Lv, Zhice Xu Tags: R A Source Type: research