Association of G308A and G238A Polymorphisms of the TNF- α Gene with Risk of Coronary Heart Disease: Systematic Review and Meta-analysis

It is widely acknowledged that coronary heart disease (CHD) has a genetic influence. One of the most promising candidate genes is tumor necrosis factor-alpha (TNF- α). Although there have been several positive studies associating the TNF-α gene and CHD, the evidence is not entirely consistent. The aim of the study was to evaluate the role of the TNF-α gene in CHD using combined evidence by generating a meta-analysis and a systematic review of all published data.

Source: Archives of Medical Research - September 30, 2016 Category: Research Authors: Karely Pulido-G ómez, Yazmín Hernández-Díaz, Carlos Alfonso Tovilla-Zárate, Isela Esther Juárez-Rojop, Thelma Beatriz González-Castro, María Lilia López-Narváez, Mariela Alpuin-Reyes Tags: Original Article Source Type: research