Population pharmacokinetics of amikacin in neonatal intensive care unit patients

Conclusion Weight and serum creatinine are associated with neonatal amikacin volume of distribution and elimination constant rate, respectively. The presence of sepsis may decrease amikacin elimination, although this observation should be further explored. These results could help to individualize amikacin dosage for neonates.
Source: Australasian Medical Journal - AMJ - Category: Journals (General) Source Type: research