Immunohistochemical Phenotype of Breast Cancer during 25-Year Follow-up of the Royal Marsden Tamoxifen Prevention Trial

In conclusion, the preventive effects of tamoxifen result in reduced ER-positive but not ER-negative tumors and reduced ER expression in the ER-positive cases largely confined to the posttreatment period. Overall reductions in PgR expression are explained by lower frequency of ER-positive cases. Impact on Ki67, HER2, and EGFR was modest. Cancer Prev Res; 10(3); 171–6. ©2017 AACR.

Source: Cancer Prevention Research - March 1, 2017 Category: Cancer & Oncology Authors: Detre, S. I., Ashley, S., Mohammed, K., Smith, I. E., Powles, T. J., Dowsett, M. Tags: Research Articles Source Type: research