Fluid shear stress induces upregulation of COX-2 and PGI2 release in endothelial cells via a pathway involving PECAM-1, PI3K, FAK, and p38

In this study we determined the major mechanotransduction pathway by which blood flow-driven shear stress activates cyclooxygenase-2 (COX-2) and prostaglandin I2 (PGI2) release in endothelial cells. Our work has demonstrated for the first time that COX-2/PGI2 mechanotransduction is mediated by the mechanosensor platelet endothelial cell adhesion molecule-1 (PECAM-1).

Source: AJP: Heart and Circulatory Physiology - February 28, 2017 Category: Cardiology Authors: Russell-Puleri, S., dela Paz, N. G., Adams, D., Chattopadhyay, M., Cancel, L., Ebong, E., Orr, A. W., Frangos, J. A., Tarbell, J. M. Tags: RESEARCH ARTICLE Source Type: research